Endocrine Abstracts

Introduction: Adrenocortical carcinoma (ACC) is a rare and aggressive tumor that accounts for 0.2% of cancer-related deaths. Case series and prospective studies are very limited due to its low prevalence. Current knowledge is based primarily on the opinions of experts in specialized units. The aim of this study is to perform a descriptive analysis of the management and prognosis of patients with ACC in HCSC in the last 20 years.Material and methods: Eigh...

Introduction: The Metabolic Syndrome (MS) is a cluster of risk factors that are related to cardiovascular disease. In Mexico, the prevalence of MS in adults according to the ENSANUT 2012 is 41%, and it has become a public health problem making it necessary to implement strategies for its management at the lowest cost possible that could encourage adherence to treatment.Objective: To evaluate the effectiveness of a comprehensive care program to achieve an...

Background: Bariatric Surgery (BS) is an effective treatment for the metabolic control of obese patients. One of its purposes is to improve the lipid profile and reduce cardiovascular risk.Aims: • To determine the changes in lipid profile and other cardiovascular risk factors before and one year after BS.• To assess differences in lipid parameters depending on the surgical procedure used.• To a...

Introduction: GH deficiency (GHD) leads to altered body composition, lipid metabolism and quality of life, and is also associated to an increased cardiovascular morbidity and mortality. The aim of this study was to evaluate long-term changes after treatment with GH replacement therapy (GHRT).Methods: We retrospectively reviewed adult patients with GHD in our clinic who were treated with GHRT. We evaluated demographic (etiology, age, dose), anthropometric...

Introduction: Tolvaptan is the only V2-receptor antagonist authorized for use in Europe in patients with SIADH. Its initiation requires hospitalization. Our goal was to analyze the safety and efficacy of tolvaptan started in a Hospital Day-Ward.Material and methods: Retrospective descriptive study of 33 ambulatory patients with mild/moderate SIADH-induced chronic sustained hyponatremia initiating tolvaptan therapy in the Day-Ward of a tertiary center ove...

Context: T regulatory type 1 (Tr1) cells are a subpopulation of T lymphocytes (CD4+CD49+LAG-3+IL-10+) lymphocytes that exerts a significant immunosuppressive effect. However, its possible role in autoimmune thyroid disease (AITD) had not been explored so far.Objective: To analyze the levels and function of Tr1 cells in peripheral blood and thyroid tissue of patients with AITD.Design: Cases and controls, observational study.<p c...

Low-renin hypertension (LRH) with normal or elevated aldosterone levels is considered part of the spectrum of aldosterone-associated hypertension, and can cause poorly-controlled hypertension. We studied patients diagnosed with LRH, comparing their clinical and biochemical characteristics with patients diagnosed with primary hyperaldosteronism (PHA). Methods Retrospective. Diagnosis in a general Endocrinology out-patient clinic ove...

Background and Objective: Gestational Diabetes Mellitus (GDM) is associated with life-long adverse outcomes for the mother and the baby. To date there is no rigorous clinical test for the assessment of GDM risk, since estimation of GDM risk is currently primarily based on clinical risk factors. Additional markers are needed to identify women at high risk. Our aim was to develop and validate a risk assessment model to identify women at high risk of GDM through an algorithm that...

Introduction: Insulinoma, despite its low incidence of 0.4%, it is the most common functioning pancreatic neuroendocrine tumor. Most are benign, solitary and sporadic. Around 10% can be malignant and 5-10% are part of MEN-1. On certain occasions, the differential diagnosis is difficult when there is a history of Diabetes Mellitus (DM). Our objective was to describe clinical-epidemiological data and its diagnostic-therapeutic management.Materials and Meth...

Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It is thought to require estrogen to have simultaneous positive and negative feedback effects on two spatially-distinct regions of the hypothalamus, the arcuate nucleus and ‘AVPV’ nucleus. However, the mechanistic basis for this differential effect is not known. Therefore, we mapped the genomic binding of the estrogen receptor alpha (ERα) in bot...